Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027.

Toxin synthesis and endospore formation are two of the most critical factors that determine the outcome of infection by Clostridioides difficile. The two major toxins, TcdA and TcdB, are the principal factors causing damage to the host. Spores are the infectious form of C. difficile, permit survival...

Full description

Bibliographic Details
Main Authors: Nadine Daou, Yuanguo Wang, Vladimir M Levdikov, Madhumitha Nandakumar, Jonathan Livny, Laurent Bouillaut, Elena Blagova, Keshan Zhang, Boris R Belitsky, Kyu Rhee, Anthony J Wilkinson, Xingmin Sun, Abraham L Sonenshein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0206896