Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse.

Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse.

Adaptive evolution is characterized by positive and parallel, or repeated selection of mutations. Mouse adaptation of influenza A virus (IAV) produces virulent mutants that demonstrate positive and parallel evolution of mutations in the hemagglutinin (HA) receptor and non-structural protein 1 (NS1)...

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Bibliographic Details
Main Authors: Jihui Ping, Liya Keleta, Nicole E Forbes, Samar Dankar, William Stecho, Shaun Tyler, Yan Zhou, Lorne Babiuk, Hana Weingartl, Rebecca A Halpin, Alex Boyne, Jayati Bera, Jessicah Hostetler, Nadia B Fedorova, Katie Proudfoot, Dan A Katzel, Tim B Stockwell, Elodie Ghedin, David J Spiro, Earl G Brown
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3128085?pdf=render

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http://europepmc.org/articles/PMC3128085?pdf=render

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