Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution
Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of human diseases, including many cancers. Mutagenic doub...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-07-01
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Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/9/7/1657 |