Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution
Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of human diseases, including many cancers. Mutagenic doub...
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doaj-88f949565f334f4285a82ae39bb3c2c92020-11-25T03:24:24ZengMDPI AGCells2073-44092020-07-0191657165710.3390/cells9071657Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome EvolutionTerrence Hanscom0Mitch McVey1Department. of Biology, Tufts University, Medford, MA 02155, USADepartment. of Biology, Tufts University, Medford, MA 02155, USADouble-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of human diseases, including many cancers. Mutagenic double-strand break repair also facilitates heritable genetic changes that drive organismal adaptation and evolution. In this review, we discuss the mechanisms of various error-prone DNA double-strand break repair processes and the cellular conditions that regulate them, with a focus on alternative end joining. We provide examples that illustrate how mutagenic double-strand break repair drives genome diversity and evolution. Finally, we discuss how error-prone break repair can be crucial to the induction and progression of diseases such as cancer.https://www.mdpi.com/2073-4409/9/7/1657alt-EJpolymerase thetamicrohomology-mediated end joiningchromosome rearrangementsresection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Terrence Hanscom Mitch McVey |
spellingShingle |
Terrence Hanscom Mitch McVey Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution Cells alt-EJ polymerase theta microhomology-mediated end joining chromosome rearrangements resection |
author_facet |
Terrence Hanscom Mitch McVey |
author_sort |
Terrence Hanscom |
title |
Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution |
title_short |
Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution |
title_full |
Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution |
title_fullStr |
Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution |
title_full_unstemmed |
Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution |
title_sort |
regulation of error-prone dna double-strand break repair and its impact on genome evolution |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-07-01 |
description |
Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of human diseases, including many cancers. Mutagenic double-strand break repair also facilitates heritable genetic changes that drive organismal adaptation and evolution. In this review, we discuss the mechanisms of various error-prone DNA double-strand break repair processes and the cellular conditions that regulate them, with a focus on alternative end joining. We provide examples that illustrate how mutagenic double-strand break repair drives genome diversity and evolution. Finally, we discuss how error-prone break repair can be crucial to the induction and progression of diseases such as cancer. |
topic |
alt-EJ polymerase theta microhomology-mediated end joining chromosome rearrangements resection |
url |
https://www.mdpi.com/2073-4409/9/7/1657 |
work_keys_str_mv |
AT terrencehanscom regulationoferrorpronednadoublestrandbreakrepairanditsimpactongenomeevolution AT mitchmcvey regulationoferrorpronednadoublestrandbreakrepairanditsimpactongenomeevolution |
_version_ |
1724601804214239232 |