Metabolic Function of a Suboptimal Transplanted Islet Mass in Nonhuman Primates on Rapamycin Monotherapy

Although islet transplantation may restore insulin independence to individuals with type 1 diabetes mellitus, most have abnormal glucose tolerance. We asked whether the defective glucose tolerance is due to inadequate β-cell mass or to impaired insulin sensitivity. We performed metabolic studies on...

Full description

Bibliographic Details
Main Authors: Scott A. Soleimanpour M.D., Boaz Hirshberg, David J. Bunnell, Anne E. Sumner, Marilyn Ader, Alan T. Remaley, Kristina I. Rother, Michael R. Rickels, David M. Harlan
Format: Article
Language:English
Published: SAGE Publishing 2012-06-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368911X603620