Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

Excitation-inhibition (E:I) imbalance is theorized as an important pathophysiological mechanism in autism. Autism affects males more frequently than females and sex-related mechanisms (e.g., X-linked genes, androgen hormones) can influence E:I balance. This suggests that E:I imbalance may affect aut...

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Bibliographic Details
Main Authors: Stavros Trakoshis, Pablo Martínez-Cañada, Federico Rocchi, Carola Canella, Wonsang You, Bhismadev Chakrabarti, Amber NV Ruigrok, Edward T Bullmore, John Suckling, Marija Markicevic, Valerio Zerbi, MRC AIMS Consortium, Simon Baron-Cohen, Alessandro Gozzi, Meng-Chuan Lai, Stefano Panzeri, Michael V Lombardo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
autism
heterogeneity
sex/gender
excitation
inhibition
fMRI
Online Access:https://elifesciences.org/articles/55684

Internet

https://elifesciences.org/articles/55684

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