Loss of skin elasticity is associated with pulmonary emphysema, biomarkers of inflammation, and matrix metalloproteinase activity in smokers

Loss of skin elasticity is associated with pulmonary emphysema, biomarkers of inflammation, and matrix metalloproteinase activity in smokers

Abstract Background Elastin breakdown and the resultant loss of lung elastic recoil is a hallmark of pulmonary emphysema in susceptible individuals as a consequence of tobacco smoke exposure. Systemic alterations to the synthesis and degradation of elastin may be important to our understanding of di...

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Bibliographic Details
Main Authors: Michael E. O’Brien, Divay Chandra, Robert C. Wilson, Chad M. Karoleski, Carl R. Fuhrman, Joseph K. Leader, Jiantao Pu, Yingze Zhang, Alison Morris, Seyed Nouraie, Jessica Bon, Zsolt Urban, Frank C. Sciurba
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Respiratory Research
Subjects:
COPD
Emphysema
Skin
Elasticity
Metalloprotease
Inflammation
Online Access:http://link.springer.com/article/10.1186/s12931-019-1098-7

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http://link.springer.com/article/10.1186/s12931-019-1098-7

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