Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease

Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease

Abstract In this mini-review, we summarize recent findings relating to the prion-like propagation of α-synuclein (α-syn) and the development of novel therapeutic strategies to target synucleinopathy in Parkinson’s disease (PD). We link the Braak’s staging hypothesis of PD with the recent evidence fr...

Full description

Bibliographic Details
Main Authors: Daniel Kam Yin Chan, Ying Hua Xu, Luke Kar Man Chan, Nady Braidy, George D. Mellick
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Translational Neurodegeneration
Subjects:
Parkinson’s disease
α-synuclein
Endocytosis
Aggregation
Online Access:http://link.springer.com/article/10.1186/s40035-017-0104-6

Internet

http://link.springer.com/article/10.1186/s40035-017-0104-6

Similar Items