Intervention against hypertension in the next generation programmed by developmental hypoxia.

Evidence derived from human clinical studies and experimental animal models shows a causal relationship between adverse pregnancy and increased cardiovascular disease in the adult offspring. However, translational studies isolating mechanisms to design intervention are lacking. Sheep and humans shar...

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Bibliographic Details
Main Authors: Kirsty L Brain, Beth J Allison, Youguo Niu, Christine M Cross, Nozomi Itani, Andrew D Kane, Emilio A Herrera, Katie L Skeffington, Kimberley J Botting, Dino A Giussani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2006552