Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

Background: A significant gap in pancreatic ductal adenocarcinoma (PDAC) patient's care is the lack of molecular parameters characterizing tumours and allowing a personalized treatment. Methods: Patient-derived xenografts (PDX) were obtained from 76 consecutive PDAC and classified according to...

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Main Authors: Rémy Nicolle, Yuna Blum, Pauline Duconseil, Charles Vanbrugghe, Nicolas Brandone, Flora Poizat, Julie Roques, Martin Bigonnet, Odile Gayet, Marion Rubis, Nabila Elarouci, Lucile Armenoult, Mira Ayadi, Aurélien de Reyniès, Marc Giovannini, Philippe Grandval, Stephane Garcia, Cindy Canivet, Jérôme Cros, Barbara Bournet, Vincent Moutardier, Marine Gilabert, Juan Iovanna, Nelson Dusetti, Louis Buscail
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:EBioMedicine
Subjects:
Pancreatic cancer
Transcriptomic signature
Chemosensitivity prediction
Prognostic
Translational medicine
Precision medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420302334

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http://www.sciencedirect.com/science/article/pii/S2352396420302334

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