Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa.

Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa.

Despite recent advances in our understanding of the pathogenesis of attaching and effacing (A/E) Escherichia coli infections, the mechanisms by which the host defends against these microbes are unclear. The goal of this study was to determine the role of goblet cell-derived Muc2, the major intestina...

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Bibliographic Details
Main Authors: Kirk S B Bergstrom, Vanessa Kissoon-Singh, Deanna L Gibson, Caixia Ma, Marinieve Montero, Ho Pan Sham, Natasha Ryz, Tina Huang, Anna Velcich, B Brett Finlay, Kris Chadee, Bruce A Vallance
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2869315?pdf=render

Internet

http://europepmc.org/articles/PMC2869315?pdf=render

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