Functional Cyclization of Eukaryotic mRNAs

Functional Cyclization of Eukaryotic mRNAs

The closed-loop model of eukaryotic translation states that mRNA is circularized by a chain of the cap-eIF4E-eIF4G-poly(A)-binding protein (PABP)-poly(A) interactions that brings 5′ and 3′ ends together. This circularization is thought to promote the engagement of terminating ribosomes to a new roun...

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Bibliographic Details
Main Authors: Olga M. Alekhina, Ilya M. Terenin, Sergey E. Dmitriev, Konstantin S. Vassilenko
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
eukaryotic mrna translation
protein synthesis
5′ cap–poly(a)-tail interaction
polysome
translation reinitiation
ribosome recycling
cell-free system
in vitro translation
Online Access:https://www.mdpi.com/1422-0067/21/5/1677

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https://www.mdpi.com/1422-0067/21/5/1677

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