Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons

Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons

We established a semi-high-throughput in vivo screening platform using hyperactive piggyBac (hyPB) transposons (designated as PB-miR) to identify microRNAs (miRs) that inhibit hepatocellular carcinoma (HCC) development in vivo, following miR overexpression in hepatocytes. PB-miRs encoding six differ...

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Bibliographic Details
Main Authors: Jaitip Tipanee, Mario Di Matteo, Warut Tulalamba, Ermira Samara-Kuko, Jiri Keirsse, Jo A. Van Ginderachter, Marinee Khim Chuah, Thierry VandenDriessche
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120300500

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http://www.sciencedirect.com/science/article/pii/S2162253120300500

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