Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons
We established a semi-high-throughput in vivo screening platform using hyperactive piggyBac (hyPB) transposons (designated as PB-miR) to identify microRNAs (miRs) that inhibit hepatocellular carcinoma (HCC) development in vivo, following miR overexpression in hepatocytes. PB-miRs encoding six differ...
Main Authors: | Jaitip Tipanee, Mario Di Matteo, Warut Tulalamba, Ermira Samara-Kuko, Jiri Keirsse, Jo A. Van Ginderachter, Marinee Khim Chuah, Thierry VandenDriessche |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-03-01
|
Series: | Molecular Therapy: Nucleic Acids |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253120300500 |
Similar Items
-
The Functionality of Minimal PiggyBac Transposons in Mammalian Cells
by: Boris Troyanovsky, et al.
Published: (2016-01-01) -
Generation of piggyBac transposon system in mammalian cells
by: Cheng-Yi Lee, et al.
Published: (2009) -
O TRANSPOSON piggyBac: QUANTIFICANDO SUA MOBILIZAÇÃO
by: Kaminski, Valéria de Lima
Published: (2016) -
Applications of piggyBac Transposons for Genome Manipulation in Stem Cells
by: Yi Sun, et al.
Published: (2021-01-01) -
Fusion of piggyBac-like transposons and herpesviruses occurs frequently in teleosts
by: Yusuke Inoue, et al.
Published: (2018-02-01)