DC-SIGN on B lymphocytes is required for transmission of HIV-1 to T lymphocytes.

DC-SIGN on B lymphocytes is required for transmission of HIV-1 to T lymphocytes.

Infection of T cells by HIV-1 can occur through binding of virus to dendritic cell (DC)-specific ICAM-3 grabbing nonintegrin (DC-SIGN) on dendritic cells and transfer of virus to CD4+ T cells. Here we show that a subset of B cells in the blood and tonsils of normal donors expressed DC-SIGN, and that...

Full description

Bibliographic Details
Main Authors: Giovanna Rappocciolo, Paolo Piazza, Craig L Fuller, Todd A Reinhart, Simon C Watkins, David T Rowe, Mariel Jais, Phalguni Gupta, Charles R Rinaldo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC1500807?pdf=render

Internet

http://europepmc.org/articles/PMC1500807?pdf=render

Similar Items