Leucine and HMB differentially modulate proteasome system in skeletal muscle under different sarcopenic conditions.

Leucine and HMB differentially modulate proteasome system in skeletal muscle under different sarcopenic conditions.

In the present study we have compared the effects of leucine supplementation and its metabolite β-hydroxy-β-methyl butyrate (HMB) on the ubiquitin-proteasome system and the PI3K/Akt pathway during two distinct atrophic conditions, hindlimb immobilization and dexamethasone treatment. Leucine suppleme...

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Bibliographic Details
Main Authors: Igor L Baptista, Willian J Silva, Guilherme G Artioli, Joao Paulo L F Guilherme, Marcelo L Leal, Marcelo S Aoki, Elen H Miyabara, Anselmo S Moriscot
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3790739?pdf=render

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http://europepmc.org/articles/PMC3790739?pdf=render

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