Leucine and HMB differentially modulate proteasome system in skeletal muscle under different sarcopenic conditions.
In the present study we have compared the effects of leucine supplementation and its metabolite β-hydroxy-β-methyl butyrate (HMB) on the ubiquitin-proteasome system and the PI3K/Akt pathway during two distinct atrophic conditions, hindlimb immobilization and dexamethasone treatment. Leucine suppleme...
Main Authors: | Igor L Baptista, Willian J Silva, Guilherme G Artioli, Joao Paulo L F Guilherme, Marcelo L Leal, Marcelo S Aoki, Elen H Miyabara, Anselmo S Moriscot |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3790739?pdf=render |
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