Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization

Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization

Izumo and Juno are receptors on sperm and eggs respectively required for fusion, but other factors for sperm-egg fusion are poorly studied. Here, the authors report that phosphatidylserine, found mainly on cells marked for death, is also present on motile sperm, recognized by egg receptors, and is r...

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Bibliographic Details
Main Authors: Claudia M. Rival, Wenhao Xu, Laura S. Shankman, Sho Morioka, Sanja Arandjelovic, Chang Sup Lee, Karen M. Wheeler, Ryan P. Smith, Lisa B. Haney, Brant E. Isakson, Scott Purcell, Jeffrey J. Lysiak, Kodi S. Ravichandran
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12406-z

Internet

https://doi.org/10.1038/s41467-019-12406-z

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