PIAS1 potentiates the anti-EBV activity of SAMHD1 through SUMOylation

PIAS1 potentiates the anti-EBV activity of SAMHD1 through SUMOylation

Abstract Background Sterile alpha motif and HD domain 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase (dNTPase) that restricts the infection of a variety of RNA and DNA viruses, including herpesviruses. The anti-viral function of SAMHD1 is associated with its dNTPase activity, which is regulated...

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Bibliographic Details
Main Authors: Farjana Saiada, Kun Zhang, Renfeng Li
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Cell & Bioscience
Subjects:
SAMHD1
PIAS1
Restriction factor
Epstein-Barr virus
Cytomegalovirus
SUMOylation
Online Access:https://doi.org/10.1186/s13578-021-00636-y

Internet

https://doi.org/10.1186/s13578-021-00636-y

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