PNPLA3 mediates hepatocyte triacylglycerol remodeling[S]

PNPLA3 mediates hepatocyte triacylglycerol remodeling[S]

The I148M substitution in patatin-like phospholipase domain containing 3 (PNPLA3I148M) determines a genetic form of nonalcoholic fatty liver disease. To elucidate the mode of PNPLA3 action in human hepatocytes, we studied effects of WT PNPLA3 (PNPLA3WT) and PNPLA3I148M on HuH7 cell lipidome after [1...

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Bibliographic Details
Main Authors: Hanna Ruhanen, Julia Perttilä, Maarit Hölttä-Vuori, You Zhou, Hannele Yki-Järvinen, Elina Ikonen, Reijo Käkelä, Vesa M. Olkkonen
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Journal of Lipid Research
Subjects:
adiponutrin
lipase
lipid droplet
lipidomics
nonalcoholic fatty liver disease
patatin-like phospholipase domain containing 3
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520376628

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http://www.sciencedirect.com/science/article/pii/S0022227520376628

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