Staphylococcal Superantigens Stimulate Epithelial Cells through CD40 To Produce Chemokines

Staphylococcal Superantigens Stimulate Epithelial Cells through CD40 To Produce Chemokines

Menstrual toxic shock syndrome (TSS) is a serious infectious disease associated with vaginal colonization by Staphylococcus aureus producing the exotoxin TSS toxin 1 (TSST-1). We show that menstrual TSS occurs after TSST-1 interaction with an immune costimulatory molecule called CD40 on the surface...

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Bibliographic Details
Main Authors: Patrick M. Schlievert, Michael P. Cahill, Bruce S. Hostager, Amanda J. Brosnahan, Aloysius J. Klingelhutz, Francoise A. Gourronc, Gail A. Bishop, Donald Y. M. Leung
Format: Article
Language:English
Published: American Society for Microbiology 2019-03-01
Series:mBio
Subjects:
CD40
Staphylococcus aureus
chemokines
superantigens
toxic shock syndrome toxin
Online Access:https://doi.org/10.1128/mBio.00214-19

Internet

https://doi.org/10.1128/mBio.00214-19

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