Phosphatidylinositol 3-kinase, phosphoinositide-specific phospholipase-Cγ and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 alone and combined with scavenger receptor-AI/II in macrophages

Phosphatidylinositol 3-kinase, phosphoinositide-specific phospholipase-Cγ and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 alone and combined with scavenger receptor-AI/II in macrophages

Complement-receptor-3 (CR3/MAC-1), scavenger-receptor-AI/II (SRAI/II) and Fcγ-receptor (FcγR) can mediate phagocytosis of degenerated myelin in macrophages and microglia. However, CR3/MAC-1 and SRAI/II, but not FcγR, mediate phagocytosis after axonal injury. We tested for phosphatidylinositol 3-kina...

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Bibliographic Details
Main Authors: Chen Makranz, Goni Cohen, Ayellet Baron, Lital Levidor, Tatsuhiko Kodama, Fanny Reichert, Shlomo Rotshenker
Format: Article
Language:English
Published: Elsevier 2004-03-01
Series:Neurobiology of Disease
Subjects:
Macrophage
Microglia
Myelin
Phagocytosis
Complement-receptor-3
Scavenger-receptor-AI/II
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103002456

Internet

http://www.sciencedirect.com/science/article/pii/S0969996103002456

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