Untargeted Metabolomics Study of the In Vitro Anti-Hepatoma Effect of Saikosaponin d in Combination with NRP-1 Knockdown

Untargeted Metabolomics Study of the In Vitro Anti-Hepatoma Effect of Saikosaponin d in Combination with NRP-1 Knockdown

Saikosaponin d (SSd) is one of the main active ingredients in Radix Bupleuri. In our study, network pharmacology databases and metabolomics were used in combination to explore the new targets and reveal the in-depth mechanism of SSd. A total of 35 potential targets were chosen through database searc...

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Bibliographic Details
Main Authors: Yingtong Lv, Xiaoying Hou, Qianqian Zhang, Ruiting Li, Lei Xu, Yadong Chen, Yuan Tian, Rong Sun, Zunjian Zhang, Fengguo Xu
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
saikosaponin d
neuropilin-1
HepG2
metabolomics
metabolite deregulation score
Online Access:https://www.mdpi.com/1420-3049/24/7/1423

Internet

https://www.mdpi.com/1420-3049/24/7/1423

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