DMD Pluripotent Stem Cell Derived Cardiac Cells Recapitulate in vitro Human Cardiac Pathophysiology

DMD Pluripotent Stem Cell Derived Cardiac Cells Recapitulate in vitro Human Cardiac Pathophysiology

Duchenne muscular dystrophy (DMD) is a severe genetic disorder characterized by the lack of functional dystrophin. DMD is associated with progressive dilated cardiomyopathy, eventually leading to heart failure as the main cause of death in DMD patients. Although several molecular mechanisms leading...

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Bibliographic Details
Main Authors: Sarka Jelinkova, Aleksandra Vilotic, Jan Pribyl, Franck Aimond, Anton Salykin, Ivana Acimovic, Martin Pesl, Guido Caluori, Simon Klimovic, Tomas Urban, Hana Dobrovolna, Vladimir Soska, Petr Skladal, Alain Lacampagne, Petr Dvorak, Albano C. Meli, Vladimir Rotrekl
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
duchenne muscular dystrophy
DMD
human pluripotent stem cells
cardiomyocytes
intracellular calcium
excitation-contraction coupling
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00535/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00535/full

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