D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model

D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model

Abstract Heterozygous mutations in glucocerebrosidase 1 (GBA1) are a major genetic risk factor for Parkinson’s disease and Dementia with Lewy bodies. Mutations in GBA1 leads to GBA1 enzyme deficiency, and GBA1-associated parkinsonism has an earlier age of onset and more progressive parkinsonism. To...

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Bibliographic Details
Main Authors: Donghoon Kim, Heehong Hwang, Seulah Choi, Sang Ho Kwon, Suhyun Lee, Jae Hong Park, SangMin Kim, Han Seok Ko
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Acta Neuropathologica Communications
Subjects:
Parkinson’s disease
Gaucher’s disease
Glucocerebrosidase 1
D409H GBA1 mutation
α-synuclein
Online Access:http://link.springer.com/article/10.1186/s40478-018-0538-9

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http://link.springer.com/article/10.1186/s40478-018-0538-9

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