Identification of 3,4-Dihydro-2<i>H</i>,6<i>H</i>-pyrimido[1,2-<i>c</i>][1,3]benzothiazin-6-imine Derivatives as Novel Selective Inhibitors of <i>Plasmodium falciparum</i> Dihydroorotate Dehydrogenase

Identification of 3,4-Dihydro-2<i>H</i>,6<i>H</i>-pyrimido[1,2-<i>c</i>][1,3]benzothiazin-6-imine Derivatives as Novel Selective Inhibitors of <i>Plasmodium falciparum</i> Dihydroorotate Dehydrogenase

<i>Plasmodium falciparum</i>’s resistance to available antimalarial drugs highlights the need for the development of novel drugs. Pyrimidine de novo biosynthesis is a validated drug target for the prevention and treatment of malaria infection. <i>P. falciparum</i> dihydroorot...

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Bibliographic Details
Main Authors: Endah Dwi Hartuti, Takaya Sakura, Mohammed S. O. Tagod, Eri Yoshida, Xinying Wang, Kota Mochizuki, Rajib Acharjee, Yuichi Matsuo, Fuyuki Tokumasu, Mihoko Mori, Danang Waluyo, Kazuro Shiomi, Tomoyoshi Nozaki, Shinjiro Hamano, Tomoo Shiba, Kiyoshi Kita, Daniel Ken Inaoka
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Plasmodium falciparum</i>
dihydroorotate dehydrogenase
inhibitor screening
ubiquinone
antimalarial drug
Online Access:https://www.mdpi.com/1422-0067/22/13/7236

Internet

https://www.mdpi.com/1422-0067/22/13/7236

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