Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging

Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging

Aging is associated with an increased susceptibility to infection and a failure to control latent viruses thought to be driven, at least in part, by alterations in CD8 T cell function. The aging T cell repertoire is characterized by an accumulation of effector CD8 T cells, many of which express the...

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Bibliographic Details
Main Authors: Claire E. Gustafson, Qian Qi, Jessica Hutter-Saunders, Sheena Gupta, Rohit Jadhav, Evan Newell, Holden Maecker, Cornelia M. Weyand, Jörg J. Goronzy
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
ILT-2
LILRB1
immunosenescence
exhaustion
NK receptors
innate-like CD8 T cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00692/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00692/full

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