A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons

A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons

PRDM14 is a critical transcription factor for mouse primordial germ cell specification, but its role in human remains unclear. Here, PRDM14 protein depletion using auxin-inducible degron uncovers a critical role for human germ cell specification, but regulation of a different set of target genes tha...

Full description

Bibliographic Details
Main Authors: Anastasiya Sybirna, Walfred W. C. Tang, Merrick Pierson Smela, Sabine Dietmann, Wolfram H. Gruhn, Ran Brosh, M. Azim Surani
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15042-0
id doaj-89513bd8995b4d72af1095f2f4ba77c1
record_format Article
spelling doaj-89513bd8995b4d72af1095f2f4ba77c12021-05-11T09:17:42ZengNature Publishing GroupNature Communications2041-17232020-03-0111111810.1038/s41467-020-15042-0A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degronsAnastasiya Sybirna0Walfred W. C. Tang1Merrick Pierson Smela2Sabine Dietmann3Wolfram H. Gruhn4Ran Brosh5M. Azim Surani6Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental BiologyWellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental BiologyWellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental BiologyWellcome Trust/Medical Research Council Cambridge Stem Cell Institute, University of CambridgeWellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental BiologyInstitute for Systems Genetics, NYU Langone HealthWellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental BiologyPRDM14 is a critical transcription factor for mouse primordial germ cell specification, but its role in human remains unclear. Here, PRDM14 protein depletion using auxin-inducible degron uncovers a critical role for human germ cell specification, but regulation of a different set of target genes than in mouse.https://doi.org/10.1038/s41467-020-15042-0
collection DOAJ
language English
format Article
sources DOAJ
author Anastasiya Sybirna
Walfred W. C. Tang
Merrick Pierson Smela
Sabine Dietmann
Wolfram H. Gruhn
Ran Brosh
M. Azim Surani
spellingShingle Anastasiya Sybirna
Walfred W. C. Tang
Merrick Pierson Smela
Sabine Dietmann
Wolfram H. Gruhn
Ran Brosh
M. Azim Surani
A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
Nature Communications
author_facet Anastasiya Sybirna
Walfred W. C. Tang
Merrick Pierson Smela
Sabine Dietmann
Wolfram H. Gruhn
Ran Brosh
M. Azim Surani
author_sort Anastasiya Sybirna
title A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
title_short A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
title_full A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
title_fullStr A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
title_full_unstemmed A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
title_sort critical role of prdm14 in human primordial germ cell fate revealed by inducible degrons
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-03-01
description PRDM14 is a critical transcription factor for mouse primordial germ cell specification, but its role in human remains unclear. Here, PRDM14 protein depletion using auxin-inducible degron uncovers a critical role for human germ cell specification, but regulation of a different set of target genes than in mouse.
url https://doi.org/10.1038/s41467-020-15042-0
work_keys_str_mv AT anastasiyasybirna acriticalroleofprdm14inhumanprimordialgermcellfaterevealedbyinducibledegrons
AT walfredwctang acriticalroleofprdm14inhumanprimordialgermcellfaterevealedbyinducibledegrons
AT merrickpiersonsmela acriticalroleofprdm14inhumanprimordialgermcellfaterevealedbyinducibledegrons
AT sabinedietmann acriticalroleofprdm14inhumanprimordialgermcellfaterevealedbyinducibledegrons
AT wolframhgruhn acriticalroleofprdm14inhumanprimordialgermcellfaterevealedbyinducibledegrons
AT ranbrosh acriticalroleofprdm14inhumanprimordialgermcellfaterevealedbyinducibledegrons
AT mazimsurani acriticalroleofprdm14inhumanprimordialgermcellfaterevealedbyinducibledegrons
AT anastasiyasybirna criticalroleofprdm14inhumanprimordialgermcellfaterevealedbyinducibledegrons
AT walfredwctang criticalroleofprdm14inhumanprimordialgermcellfaterevealedbyinducibledegrons
AT merrickpiersonsmela criticalroleofprdm14inhumanprimordialgermcellfaterevealedbyinducibledegrons
AT sabinedietmann criticalroleofprdm14inhumanprimordialgermcellfaterevealedbyinducibledegrons
AT wolframhgruhn criticalroleofprdm14inhumanprimordialgermcellfaterevealedbyinducibledegrons
AT ranbrosh criticalroleofprdm14inhumanprimordialgermcellfaterevealedbyinducibledegrons
AT mazimsurani criticalroleofprdm14inhumanprimordialgermcellfaterevealedbyinducibledegrons
_version_ 1721450114598305792

Similar Items