Blocking Thrombin Significantly Ameliorates Experimental Autoimmune Neuritis

Blocking Thrombin Significantly Ameliorates Experimental Autoimmune Neuritis

Thrombin and its protease-activated receptor 1 (PAR1) are potentially important in peripheral nerve inflammatory diseases. We studied the role of thrombin and PAR1 in rat experimental autoimmune neuritis (EAN), a model of the human Guillain-Barré syndrome (GBS). EAN was induced by bovine peripheral...

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Bibliographic Details
Main Authors: Efrat Shavit-Stein, Ramona Aronovich, Constantin Sylantiev, Orna Gera, Shany G. Gofrit, Joab Chapman, Amir Dori
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Neurology
Subjects:
thrombin
experimental autoimmune neuritis
node of Ranvier
PAR1
Guillain-Barré syndrome
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.01139/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.01139/full

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