Drug-excipient behavior in polymeric amorphous solid dispersions
Amorphous drug delivery systems are increasingly utilized to enhance aqueous solubility and oral bioavailability. However, they lack physical and/or chemical stability. One of the most common ways of stabilizing an amorphous form is by formulating it as an amorphous solid dispersion. This review foc...
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doaj-895e8161341a4ea192a90cae07a959b52020-11-24T23:58:06ZengInternational Pharmaceutical Excipients CouncilJournal of Excipients and Food Chemicals2150-2668Drug-excipient behavior in polymeric amorphous solid dispersionsSurikutchi Bhanu TejaShashank Pralhad PatilGanesh SheteSarsvatkumar PatelArvind Kumar BansalAmorphous drug delivery systems are increasingly utilized to enhance aqueous solubility and oral bioavailability. However, they lack physical and/or chemical stability. One of the most common ways of stabilizing an amorphous form is by formulating it as an amorphous solid dispersion. This review focuses on polymeric amorphous solid dispersions wherein polymers are used as excipients to stabilize the amorphous form. A brief introduction to the basic concepts of amorphous systems such as glass transition temperature and the solubility advantage of amorphous systems is provided. Additionally, information on types of polymers used for the development of amorphous solid dispersions, their structural attributes and mechanisms of stabilization are presented here. Molecular aspects of drug-polymer miscibility and drugpolymer interactions are also discussed.http://jefc.scholasticahq.com/article/1048-drug-excipient-behavior-in-polymeric-amorphous-solid-dispersions.pdf |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Surikutchi Bhanu Teja Shashank Pralhad Patil Ganesh Shete Sarsvatkumar Patel Arvind Kumar Bansal |
spellingShingle |
Surikutchi Bhanu Teja Shashank Pralhad Patil Ganesh Shete Sarsvatkumar Patel Arvind Kumar Bansal Drug-excipient behavior in polymeric amorphous solid dispersions Journal of Excipients and Food Chemicals |
author_facet |
Surikutchi Bhanu Teja Shashank Pralhad Patil Ganesh Shete Sarsvatkumar Patel Arvind Kumar Bansal |
author_sort |
Surikutchi Bhanu Teja |
title |
Drug-excipient behavior in polymeric amorphous solid dispersions |
title_short |
Drug-excipient behavior in polymeric amorphous solid dispersions |
title_full |
Drug-excipient behavior in polymeric amorphous solid dispersions |
title_fullStr |
Drug-excipient behavior in polymeric amorphous solid dispersions |
title_full_unstemmed |
Drug-excipient behavior in polymeric amorphous solid dispersions |
title_sort |
drug-excipient behavior in polymeric amorphous solid dispersions |
publisher |
International Pharmaceutical Excipients Council |
series |
Journal of Excipients and Food Chemicals |
issn |
2150-2668 |
description |
Amorphous drug delivery systems are increasingly utilized to enhance aqueous solubility and oral bioavailability. However, they lack physical and/or chemical stability. One of the most common ways of stabilizing an amorphous form is by formulating it as an amorphous solid dispersion. This review focuses on polymeric amorphous solid dispersions wherein polymers are used as excipients to stabilize the amorphous form. A brief introduction to the basic concepts of amorphous systems such as glass transition temperature and the solubility advantage of amorphous systems is provided. Additionally, information on types of polymers used for the development of amorphous solid dispersions, their structural attributes and mechanisms of stabilization are presented here. Molecular aspects of drug-polymer miscibility and drugpolymer interactions are also discussed. |
url |
http://jefc.scholasticahq.com/article/1048-drug-excipient-behavior-in-polymeric-amorphous-solid-dispersions.pdf |
work_keys_str_mv |
AT surikutchibhanuteja drugexcipientbehaviorinpolymericamorphoussoliddispersions AT shashankpralhadpatil drugexcipientbehaviorinpolymericamorphoussoliddispersions AT ganeshshete drugexcipientbehaviorinpolymericamorphoussoliddispersions AT sarsvatkumarpatel drugexcipientbehaviorinpolymericamorphoussoliddispersions AT arvindkumarbansal drugexcipientbehaviorinpolymericamorphoussoliddispersions |
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1725451926305243136 |