Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2

Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2

Abstract Background Pamamycins are macrodiolides of polyketide origin which form a family of differently large homologues with molecular weights between 579 and 663. They offer promising biological activity against pathogenic fungi and gram-positive bacteria. Admittedly, production titers are very l...

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Bibliographic Details
Main Authors: Lars Gläser, Martin Kuhl, Julian Stegmüller, Christian Rückert, Maksym Myronovskyi, Jörn Kalinowski, Andriy Luzhetskyy, Christoph Wittmann
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Microbial Cell Factories
Subjects:
Polyketide
Transcriptome
Metabolome
bkdR
l-valine
CoA thioester
Online Access:https://doi.org/10.1186/s12934-021-01602-6

Internet

https://doi.org/10.1186/s12934-021-01602-6

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