Loss of the thioredoxin reductase Trr1 suppresses the genomic instability of peroxiredoxin tsa1 mutants.

Loss of the thioredoxin reductase Trr1 suppresses the genomic instability of peroxiredoxin tsa1 mutants.

The absence of Tsa1, a key peroxiredoxin that scavenges H2O2 in Saccharomyces cerevisiae, causes the accumulation of a broad spectrum of mutations. Deletion of TSA1 also causes synthetic lethality in combination with mutations in RAD51 or several key genes involved in DNA double-strand break repair....

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Bibliographic Details
Main Authors: Sandrine Ragu, Michèle Dardalhon, Sushma Sharma, Ismail Iraqui, Géraldine Buhagiar-Labarchède, Virginie Grondin, Guy Kienda, Laurence Vernis, Roland Chanet, Richard D Kolodner, Meng-Er Huang, Gérard Faye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4172583?pdf=render

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http://europepmc.org/articles/PMC4172583?pdf=render

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