Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity

Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity

While it is now acknowledged that CD4+ T cells expressing CD25 and Foxp3 (Treg cells) regulate immune responses and, consequently, influence the pathogenesis of infectious diseases, the regulatory response mediated by Treg cells upon infection by Trypanosoma cruzi was still poorly characterized. In...

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Bibliographic Details
Main Authors: Cintia L. Araujo Furlan, Jimena Tosello Boari, Constanza Rodriguez, Fernando P. Canale, Facundo Fiocca Vernengo, Santiago Boccardo, Cristian G. Beccaria, Véronique Adoue, Olivier Joffre, Adriana Gruppi, Carolina L. Montes, Eva V. Acosta Rodriguez
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
regulatory T (Treg) cells
Trypanosoma cruzi
immunity
CD8 cytotoxic T cells+
pathogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02555/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02555/full

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