Chlamydia abortus Pmp18.1 Induces IL-1β Secretion by TLR4 Activation through the MyD88, NF-κB, and Caspase-1 Signaling Pathways

Chlamydia abortus Pmp18.1 Induces IL-1β Secretion by TLR4 Activation through the MyD88, NF-κB, and Caspase-1 Signaling Pathways

The polymorphic membrane protein D (Pmp18D) is a 160-kDa outer membrane protein that is conserved and plays an important role in Chlamydia abortus pathogenesis. We have identified an N-terminal fragment of Pmp18D (designated Pmp18.1) as a possible subunit vaccine antigen. In this study, we evaluated...

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Bibliographic Details
Main Authors: Qing Pan, Qiang Zhang, Jun Chu, Roshan Pais, Shanshan Liu, Cheng He, Francis O. Eko
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Chlamydia abortus
dendritic cells
Pmp18D
TLR4
NF-κB signaling
IL-1β
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00514/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00514/full

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