Adipocyte-specific DKO of Lkb1 and mTOR protects mice against HFD-induced obesity, but results in insulin resistance

Adipocyte-specific DKO of Lkb1 and mTOR protects mice against HFD-induced obesity, but results in insulin resistance

Liver kinase B1 (Lkb1) and mammalian target of rapamycin (mTOR) are key regulators of energy metabolism and cell growth. We have previously reported that adipocyte-specific KO of Lkb1 or mTOR in mice results in distinct developmental and metabolic phenotypes. Here, we aimed to assess how genetic KO...

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Bibliographic Details
Main Authors: Yan Xiong, Ziye Xu, Yizhen Wang, Shihuan Kuang, Tizhong Shan
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Journal of Lipid Research
Subjects:
adipose
metabolism
liver kinase B1
mammalian target of rapamycin
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520330960

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http://www.sciencedirect.com/science/article/pii/S0022227520330960

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