Galectin-1 circumvents lysolecithin-induced demyelination through the modulation of microglial polarization/phagocytosis and oligodendroglial differentiation

Galectin-1 circumvents lysolecithin-induced demyelination through the modulation of microglial polarization/phagocytosis and oligodendroglial differentiation

Galectin-1 (Gal-1), a member of a highly conserved family of animal lectins, binds to the common disaccharide [Galβ(1-4)-GlcNAc] on both N- and O-glycans decorating cell surface glycoconjugates. Current evidence supports a role for Gal-1 in the pathophysiology of multiple sclerosis (MS), one of the...

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Bibliographic Details
Main Authors: Mariana Rinaldi, Laura Thomas, Patricia Mathieu, Pablo Carabias, Maria F. Troncoso, Juana M. Pasquini, Gabriel A. Rabinovich, Laura A. Pasquini
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Neurobiology of Disease
Subjects:
Galectin-1
Demyelination-remyelination
Microglia
Lysolecithin
Phagocytosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302194

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http://www.sciencedirect.com/science/article/pii/S0969996116302194

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