MET Receptor Tyrosine Kinase Regulates the Expression of Co-Stimulatory and Co-Inhibitory Molecules in Tumor Cells and Contributes to PD-L1-Mediated Suppression of Immune Cell Function

MET Receptor Tyrosine Kinase Regulates the Expression of Co-Stimulatory and Co-Inhibitory Molecules in Tumor Cells and Contributes to PD-L1-Mediated Suppression of Immune Cell Function

The MET tyrosine receptor kinase is essential for embryonic development and tissue regeneration by promoting cell survival, proliferation, migration, and angiogenesis. It also contributes to tumor development and progression through diverse mechanisms. Using human cancer cell lines, including Hs746T...

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Bibliographic Details
Main Authors: Hyun Kyung Ahn, Sehui Kim, Dohee Kwon, Jaemoon Koh, Young A. Kim, Kwangsoo Kim, Doo Hyun Chung, Yoon Kyung Jeon
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
MET
immune evasion
immune checkpoint
co-stimulatory molecules
co-inhibitory molecules
PD-1/PD-L1 pathway
PD-L1
cancer immunotherapy
lung cancer
Online Access:https://www.mdpi.com/1422-0067/20/17/4287

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https://www.mdpi.com/1422-0067/20/17/4287

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