From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson’s Disease: Lessons From LRRK2

From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson’s Disease: Lessons From LRRK2

The pathogenesis of Parkinson’s disease (PD) is thought to rely on a complex interaction between the patient’s genetic background and a variety of largely unknown environmental factors. In this scenario, the investigation of the genetic bases underlying familial PD could unveil key molecular pathway...

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Bibliographic Details
Main Authors: Andrea Mancini, Petra Mazzocchetti, Miriam Sciaccaluga, Alfredo Megaro, Laura Bellingacci, Dayne A. Beccano-Kelly, Massimiliano Di Filippo, Alessandro Tozzi, Paolo Calabresi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Parkinson’s disease
LRRK2
synaptic dysfunction
mitochondrial dysfunction
α-synuclein
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00158/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00158/full

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