Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice

Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice

Viral encephalomyelitis is an important cause of long-term disability, as well as acute fatal disease. Identifying viral determinants of outcome helps in assessing disease severity and developing new treatments. Mosquito-borne alphaviruses infect neurons and cause fatal disease in mice. The highly c...

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Bibliographic Details
Main Authors: Rachy Abraham, Robert L. McPherson, Morgan Dasovich, Mohsen Badiee, Anthony K. L. Leung, Diane E. Griffin
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
alphavirus
macrodomain
adp-ribosyl hydrolase
adp-ribosyl-binding activity
innate immune response
antibody
encephalomyelitis
sindbis virus
nsp3
Online Access:https://doi.org/10.1128/mBio.03253-19

Internet

https://doi.org/10.1128/mBio.03253-19

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