Synthesis, Spatial Structure and Analgesic Activity of Sodium 3-Benzylaminocarbonyl-1-methyl-2,2-dioxo-1H-2λ6,1-benzothiazin-4-olate Solvates

Synthesis, Spatial Structure and Analgesic Activity of Sodium 3-Benzylaminocarbonyl-1-methyl-2,2-dioxo-1H-2λ6,1-benzothiazin-4-olate Solvates

In order to obtain and then test pharmocologically any possible conformers of the new feasible analgesic N-benzyl-4-hydroxy-1-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide, its 4-O-sodium salt was synthesized using two methods. X-ray diffraction study made possible to determine that, dependi...

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Bibliographic Details
Main Authors: Igor V. Ukrainets, Lidiya A. Petrushova, Svitlana V. Shishkina, Lina A. Grinevich, Galina Sim
Format: Article
Language:English
Published: Österreichische Apotheker-Verlagsgesellschaft m. b. H. 2016-10-01
Series:Scientia Pharmaceutica
Subjects:
analgesic activity
conformation
conformer
crystal structure
4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide
solvate
Online Access:http://www.mdpi.com/2218-0532/84/4/705

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http://www.mdpi.com/2218-0532/84/4/705

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