Generation of iPSC line from MYH7 R403L mutation carrier with severe hypertrophic cardiomyopathy and isogenic CRISPR/Cas9 corrected control

Generation of iPSC line from MYH7 R403L mutation carrier with severe hypertrophic cardiomyopathy and isogenic CRISPR/Cas9 corrected control

MYH7 is a major gene responsible for hypertrophic cardiomyopathy (HCM). From patient’s skin fibroblasts, we derived an iPSC line (CDGEN1.16) harboring the heterozygous MYH7 R403L mutation, a hot-spot codon in HCM. We subsequently corrected the mutated codon using CRISPR/Cas9 editing and obtained the...

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Bibliographic Details
Main Authors: Vincent Fontaine, Laetitia Duboscq-Bidot, Charlène Jouve, Matthieu Hamlin, Angélique Curjol, Véronique Briand, Philip Janiak, Jean-Sébastien Hulot, Marie-Pierre Pruniaux-Harnist, Philippe Charron, Eric Villard
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S187350612100091X

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http://www.sciencedirect.com/science/article/pii/S187350612100091X

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