The MicroRNA MiR-29c Alleviates Renal Fibrosis via TPM1-Mediated Suppression of the Wnt/β-Catenin Pathway

The MicroRNA MiR-29c Alleviates Renal Fibrosis via TPM1-Mediated Suppression of the Wnt/β-Catenin Pathway

PurposeThis study aimed to evaluate the mechanism by which miR-29c expression in fibroblasts regulates renal interstitial fibrosis.MethodsWe stimulated NRK-49F cells with TGF-β1 to mimic the effects of fibrosis in vitro, while unilateral ureteral obstruction (UUO) was performed to obstruct the mid-u...

Full description

Bibliographic Details
Main Authors: Huiya Huang, Xiaozhong Huang, Shengnan Luo, Huidi Zhang, Feifei Hu, Ruyi Chen, Chaoxing Huang, Zhen Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Physiology
Subjects:
miR-29c
fibrosis
Wnt
β-catenin
TPM1
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00331/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00331/full

Similar Items