Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in a mutant mouse model of Rett syndrome

Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in a mutant mouse model of Rett syndrome

Motor and cognitive functions are severely impaired in Rett syndrome (RTT). Here, we examined local synaptic circuits of layer 2/3 (L2/3) pyramidal neurons in motor-frontal cortex of male hemizygous MeCP2-null mice at 3 to 4 weeks of age. We mapped local excitatory input to L2/3 neurons using glutam...

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Bibliographic Details
Main Authors: Lydia Wood, Gordon M.G. Shepherd
Format: Article
Language:English
Published: Elsevier 2010-05-01
Series:Neurobiology of Disease
Subjects:
MeCP2
Rett syndrome
Cortical circuits
Circuitopathy
Laser scanning photostimulation
Glutamate uncaging
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110000343

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http://www.sciencedirect.com/science/article/pii/S0969996110000343

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