Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

<p>Abstract</p> <p>Background</p> <p>β-site APP cleaving enzyme 1 (BACE1) cleaves β-amyloid precursor protein (APP) to initiate the production of β-amyloid (Aβ), the prime culprit in Alzheimer’s disease (AD). Dysregulation of the intracellular trafficking of BACE1 may a...

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Bibliographic Details
Main Authors: Zhao Yonghao, Wang Yunshu, Yang Jiaye, Wang Xin, Zhao Yingjun, Zhang Xian, Zhang Yun-wu
Format: Article
Language:English
Published: BMC 2012-06-01
Series:Molecular Neurodegeneration
Subjects:
β-amyloid
β-amyloid precursor protein
β-site APP cleaving enzyme 1
Alzheimer’s disease
Intracellular trafficking
Sorting nexin 12.
Online Access:http://www.molecularneurodegeneration.com/content/7/1/30

Internet

http://www.molecularneurodegeneration.com/content/7/1/30

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