A Novel Framework for Characterizing Genomic Haplotype Diversity in the Human Immunoglobulin Heavy Chain Locus

A Novel Framework for Characterizing Genomic Haplotype Diversity in the Human Immunoglobulin Heavy Chain Locus

An incomplete ascertainment of genetic variation within the highly polymorphic immunoglobulin heavy chain locus (IGH) has hindered our ability to define genetic factors that influence antibody-mediated processes. Due to locus complexity, standard high-throughput approaches have failed to accurately...

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Bibliographic Details
Main Authors: Oscar L. Rodriguez, William S. Gibson, Tom Parks, Matthew Emery, James Powell, Maya Strahl, Gintaras Deikus, Kathryn Auckland, Evan E. Eichler, Wayne A. Marasco, Robert Sebra, Andrew J. Sharp, Melissa L. Smith, Ali Bashir, Corey T. Watson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
immunoglobulin heavy chain locus
single nucleotide variation
structural variation
antibody
B cell receptor
long-read sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02136/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.02136/full

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