MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus

In Myxococcus xanthus, directed movement is controlled by pole-to-pole oscillations of the small GTPase MglA and its GAP MglB. Here authors report the complete MglA/MglB structural cycle and uncover that MglA is a three-state GTPase that adopts an atypical GTP-bound state that is refractory to inact...

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Bibliographic Details
Main Authors: Christian Galicia, Sébastien Lhospice, Paloma Fernández Varela, Stefano Trapani, Wenhua Zhang, Jorge Navaza, Julien Herrou, Tâm Mignot, Jacqueline Cherfils
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13274-3