Novel Antioxidant, Deethylated Ethoxyquin, Protects against Carbon Tetrachloride Induced Hepatotoxicity in Rats by Inhibiting NLRP3 Inflammasome Activation and Apoptosis

Novel Antioxidant, Deethylated Ethoxyquin, Protects against Carbon Tetrachloride Induced Hepatotoxicity in Rats by Inhibiting NLRP3 Inflammasome Activation and Apoptosis

Inflammation and an increase in antioxidant responses mediated by oxidative stress play an important role in the pathogenesis of acute liver injury (ALI). We utilized in silico prediction of biological activity spectra for substances (PASS) analysis to estimate the potential biological activity prof...

Full description

Bibliographic Details
Main Authors: Igor Y. Iskusnykh, Evgenii D. Kryl’skii, Darya A. Brazhnikova, Tatyana N. Popova, Khidmet S. Shikhaliev, Konstantin K. Shulgin, Larisa V. Matasova, Sergey S. Popov, Dmitry A. Zhaglin, Anastasia A. Zakharova, Nelli R. Popova, Nikolai Fattakhov
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Antioxidants
Subjects:
acute liver injury
carbon tetrachloride
ethoxyquin
deethylated ethoxyquin
oxidative stress
inflammasome
Online Access:https://www.mdpi.com/2076-3921/10/1/122

Internet

https://www.mdpi.com/2076-3921/10/1/122

Similar Items