IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals
Our understanding of the immune response to SARS-CoV-2 infection is still incomplete. Here, the authors find that IL-33, produced during immune recall potentially by CD14+ monocytes, correlates with CD4+ T cell activation, anti-SARS-CoV-2 antibody titer, and disease severity in a cohort of convalesc...
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doaj-89933778592e495dada140299ff2f8c52021-04-11T11:12:37ZengNature Publishing GroupNature Communications2041-17232021-04-011211910.1038/s41467-021-22449-wIL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individualsMichal A. Stanczak0David E. Sanin1Petya Apostolova2Gabriele Nerz3Dimitrios Lampaki4Maike Hofmann5Daniel Steinmann6Marvin Krohn-Grimberghe7Robert Thimme8Gerhard Mittler9Cornelius F. Waller10Edward J. Pearce11Erika L. Pearce12Department of Immunometabolism, Max Planck Institute of Immunobiology and EpigeneticsDepartment of Immunometabolism, Max Planck Institute of Immunobiology and EpigeneticsDepartment of Immunometabolism, Max Planck Institute of Immunobiology and EpigeneticsProteomics, Max Planck Institute of Immunobiology and EpigeneticsProteomics, Max Planck Institute of Immunobiology and EpigeneticsDepartment of Medicine II, Medical Center-University of Freiburg, Faculty of Medicine, University of FreiburgOccupational Medical Service, Medical Center-University of Freiburg, Faculty of Medicine, University of FreiburgDepartment of Cardiology and Angiology I, University Heart Center FreiburgDepartment of Medicine II, Medical Center-University of Freiburg, Faculty of Medicine, University of FreiburgProteomics, Max Planck Institute of Immunobiology and EpigeneticsDepartment of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of FreiburgDepartment of Immunometabolism, Max Planck Institute of Immunobiology and EpigeneticsDepartment of Immunometabolism, Max Planck Institute of Immunobiology and EpigeneticsOur understanding of the immune response to SARS-CoV-2 infection is still incomplete. Here, the authors find that IL-33, produced during immune recall potentially by CD14+ monocytes, correlates with CD4+ T cell activation, anti-SARS-CoV-2 antibody titer, and disease severity in a cohort of convalescent individuals professionally exposed to the virus.https://doi.org/10.1038/s41467-021-22449-w |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michal A. Stanczak David E. Sanin Petya Apostolova Gabriele Nerz Dimitrios Lampaki Maike Hofmann Daniel Steinmann Marvin Krohn-Grimberghe Robert Thimme Gerhard Mittler Cornelius F. Waller Edward J. Pearce Erika L. Pearce |
spellingShingle |
Michal A. Stanczak David E. Sanin Petya Apostolova Gabriele Nerz Dimitrios Lampaki Maike Hofmann Daniel Steinmann Marvin Krohn-Grimberghe Robert Thimme Gerhard Mittler Cornelius F. Waller Edward J. Pearce Erika L. Pearce IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals Nature Communications |
author_facet |
Michal A. Stanczak David E. Sanin Petya Apostolova Gabriele Nerz Dimitrios Lampaki Maike Hofmann Daniel Steinmann Marvin Krohn-Grimberghe Robert Thimme Gerhard Mittler Cornelius F. Waller Edward J. Pearce Erika L. Pearce |
author_sort |
Michal A. Stanczak |
title |
IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals |
title_short |
IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals |
title_full |
IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals |
title_fullStr |
IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals |
title_full_unstemmed |
IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals |
title_sort |
il-33 expression in response to sars-cov-2 correlates with seropositivity in covid-19 convalescent individuals |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2021-04-01 |
description |
Our understanding of the immune response to SARS-CoV-2 infection is still incomplete. Here, the authors find that IL-33, produced during immune recall potentially by CD14+ monocytes, correlates with CD4+ T cell activation, anti-SARS-CoV-2 antibody titer, and disease severity in a cohort of convalescent individuals professionally exposed to the virus. |
url |
https://doi.org/10.1038/s41467-021-22449-w |
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