IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals

Our understanding of the immune response to SARS-CoV-2 infection is still incomplete. Here, the authors find that IL-33, produced during immune recall potentially by CD14+ monocytes, correlates with CD4+ T cell activation, anti-SARS-CoV-2 antibody titer, and disease severity in a cohort of convalesc...

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Main Authors:	Michal A. Stanczak, David E. Sanin, Petya Apostolova, Gabriele Nerz, Dimitrios Lampaki, Maike Hofmann, Daniel Steinmann, Marvin Krohn-Grimberghe, Robert Thimme, Gerhard Mittler, Cornelius F. Waller, Edward J. Pearce, Erika L. Pearce
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-22449-w

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spelling	doaj-89933778592e495dada140299ff2f8c52021-04-11T11:12:37ZengNature Publishing GroupNature Communications2041-17232021-04-011211910.1038/s41467-021-22449-wIL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individualsMichal A. Stanczak0David E. Sanin1Petya Apostolova2Gabriele Nerz3Dimitrios Lampaki4Maike Hofmann5Daniel Steinmann6Marvin Krohn-Grimberghe7Robert Thimme8Gerhard Mittler9Cornelius F. Waller10Edward J. Pearce11Erika L. Pearce12Department of Immunometabolism, Max Planck Institute of Immunobiology and EpigeneticsDepartment of Immunometabolism, Max Planck Institute of Immunobiology and EpigeneticsDepartment of Immunometabolism, Max Planck Institute of Immunobiology and EpigeneticsProteomics, Max Planck Institute of Immunobiology and EpigeneticsProteomics, Max Planck Institute of Immunobiology and EpigeneticsDepartment of Medicine II, Medical Center-University of Freiburg, Faculty of Medicine, University of FreiburgOccupational Medical Service, Medical Center-University of Freiburg, Faculty of Medicine, University of FreiburgDepartment of Cardiology and Angiology I, University Heart Center FreiburgDepartment of Medicine II, Medical Center-University of Freiburg, Faculty of Medicine, University of FreiburgProteomics, Max Planck Institute of Immunobiology and EpigeneticsDepartment of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of FreiburgDepartment of Immunometabolism, Max Planck Institute of Immunobiology and EpigeneticsDepartment of Immunometabolism, Max Planck Institute of Immunobiology and EpigeneticsOur understanding of the immune response to SARS-CoV-2 infection is still incomplete. Here, the authors find that IL-33, produced during immune recall potentially by CD14+ monocytes, correlates with CD4+ T cell activation, anti-SARS-CoV-2 antibody titer, and disease severity in a cohort of convalescent individuals professionally exposed to the virus.https://doi.org/10.1038/s41467-021-22449-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Michal A. Stanczak David E. Sanin Petya Apostolova Gabriele Nerz Dimitrios Lampaki Maike Hofmann Daniel Steinmann Marvin Krohn-Grimberghe Robert Thimme Gerhard Mittler Cornelius F. Waller Edward J. Pearce Erika L. Pearce
spellingShingle	Michal A. Stanczak David E. Sanin Petya Apostolova Gabriele Nerz Dimitrios Lampaki Maike Hofmann Daniel Steinmann Marvin Krohn-Grimberghe Robert Thimme Gerhard Mittler Cornelius F. Waller Edward J. Pearce Erika L. Pearce IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals Nature Communications
author_facet	Michal A. Stanczak David E. Sanin Petya Apostolova Gabriele Nerz Dimitrios Lampaki Maike Hofmann Daniel Steinmann Marvin Krohn-Grimberghe Robert Thimme Gerhard Mittler Cornelius F. Waller Edward J. Pearce Erika L. Pearce
author_sort	Michal A. Stanczak
title	IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals
title_short	IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals
title_full	IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals
title_fullStr	IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals
title_full_unstemmed	IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals
title_sort	il-33 expression in response to sars-cov-2 correlates with seropositivity in covid-19 convalescent individuals
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-04-01
description	Our understanding of the immune response to SARS-CoV-2 infection is still incomplete. Here, the authors find that IL-33, produced during immune recall potentially by CD14+ monocytes, correlates with CD4+ T cell activation, anti-SARS-CoV-2 antibody titer, and disease severity in a cohort of convalescent individuals professionally exposed to the virus.
url	https://doi.org/10.1038/s41467-021-22449-w
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IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals

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