Dexamethasone Attenuates X-Ray-Induced Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle in Breast Tissue and Subsequent Breast Fibrosis

Dexamethasone Attenuates X-Ray-Induced Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle in Breast Tissue and Subsequent Breast Fibrosis

We recently showed that radiation-induced DNA damage in breast adipose tissue increases autotaxin secretion, production of lysophosphatidate (LPA) and expression of LPA<sub>1/2</sub> receptors. We also established that dexamethasone decreases autotaxin production and LPA signaling in non...

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Bibliographic Details
Main Authors: Guanmin Meng, Melinda Wuest, Xiaoyun Tang, Jennifer Dufour, Todd P.W. McMullen, Frank Wuest, David Murray, David N. Brindley
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
adipocytes
adipose tissue
chemokines
cytokines
breast cancer
vasculitis
Online Access:https://www.mdpi.com/2072-6694/12/4/999

Internet

https://www.mdpi.com/2072-6694/12/4/999

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