Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice

Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice

Abstract Cytosolic Malic Enzyme (ME1) provides reduced NADP for anabolism and maintenance of redox status. To examine the role of ME1 in tumor genesis of the gastrointestinal tract, we crossed mice having augmented intestinal epithelial expression of ME1 (ME1-Tg mice) with ApcMin/+ mice to obtain ma...

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Bibliographic Details
Main Authors: Lorenzo M. Fernandes, Ahmed Al-Dwairi, Rosalia C. M. Simmen, Meera Marji, Dustin M. Brown, Sarah W. Jewell, Frank A. Simmen
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Scientific Reports
Subjects:
Apc Min
Male ApcMin
Crypt Depth
Villus Length
Villus Lamina Propria
Online Access:https://doi.org/10.1038/s41598-018-32532-w

Internet

https://doi.org/10.1038/s41598-018-32532-w

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